Sympathetic Nerves Positively Regulate Eosinophil-Driven Allergic Conjunctivitis via α1-Adrenergic Receptor Signaling

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Eosinophils are a major cause of tissue injury in allergic conjunctivitis. The biological nature of eosinophils in the conjunctiva and the mechanisms that control eosinophils’ responses in allergic conjunctivitis are currently not completely understood. Here, we report that conjunctival eosinophils comprise two populations—Siglec─Fint and Siglec─Fhi—in different life stages. Siglec─Fint eosinophils partly expressed CD34 and were in the immature (or steady) state. Siglec─Fhi eosinophils did not express CD34, sharply increased in number after short ragweed (SRW) pollen challenge, and were in the mature (or activated) state.... Read more at the The American Journal of Pathology Blog.

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