The Hippo Effector TAZ Cooperates with Oncogenic β-catenin to Induce Hepatoblastoma Development in Mice and Humans

May 18, 2020 | Histopathology

First published on The American Journal of Pathology, here is a noteworthy article for your Histopathology industry news fix:

Hepatoblastoma (HB) is the most common pediatric liver tumor. Though Wnt/β-catenin and Hippo cascades are implicated in HB development, studies on the crosstalk between β-catenin and Hippo downstream effector TAZ in HB are lacking.Expression of TAZ and β-catenin in human HB specimens was assessed by immunohistochemistry (IHC). Functional interplay between TAZ and β-catenin was determined by overexpressing an activated form of TAZ (TAZS89A) either alone or in combination with an oncogenic form of β-catenin (ΔN90-β-catenin) in the mouse liver via hydrodynamic transfection... More of this in The American Journal of Pathology Blog.

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