The Thyromimetic, GC-1, Alters Bile Acid Metabolism in a Mouse Model of Hepatic Cholestasis

April 24, 2020 | Histopathology

No need to search high and low for the latest Pathology industry news as Lab.Equipment guarantees you are updated no matter where you are. This week’s article is curated from The American Journal of Pathology:

Chronic cholestasis results from bile secretory defects or impaired bile flow with few effective medical therapies available. Thyroid hormone triiodothyronine and synthetic thyroid hormone receptor agonists, such as GC-1, are known to impact lipid and bile acid (BA) metabolism and induce hepatocyte proliferation downstream of Wnt/β-catenin signaling after surgical resection; however, these drugs have yet to be studied as potential therapeutics for cholestatic liver disease. Here, GC-1 was administered to ATP binding cassette subfamily B member 4 (Abcb4-/-; Mdr2-/-) knockout (KO) mice, a sclerosing cholangitis model.... Want to read more? Visit the The American Journal of Pathology​ Blog.

If you're in the Histopath industry and are in need of versatile Pathology equipment for histopathological examinations or basic and advanced applications, then you have come to the right place. Lab.Equipment supplies an extensive selection of equipment for laboratories analyzing and running various histophatological tests. Go through our recommended Histopath equipment like lab balances, lab centrifuges, lab pipettes, and more here.

We showcase lab equipment from well-recognized MFGs like

Working on other scientific or industrial applications? No worries. We got you covered. Explore our selection of reliable lab equipment for pharmaceutical, veterinary, cannabis applications and more.

Back To Top
We are fully compliant with the GDPR laws. We promise to safeguard your data and protect your privacy rights.