The Thyromimetic, GC-1, Alters Bile Acid Metabolism in a Mouse Model of Hepatic Cholestasis
April 24, 2020 | Histopathology
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Chronic cholestasis results from bile secretory defects or impaired bile flow with few effective medical therapies available. Thyroid hormone triiodothyronine and synthetic thyroid hormone receptor agonists, such as GC-1, are known to impact lipid and bile acid (BA) metabolism and induce hepatocyte proliferation downstream of Wnt/β-catenin signaling after surgical resection; however, these drugs have yet to be studied as potential therapeutics for cholestatic liver disease. Here, GC-1 was administered to ATP binding cassette subfamily B member 4 (Abcb4-/-; Mdr2-/-) knockout (KO) mice, a sclerosing cholangitis model.... Want to read more? Visit the The American Journal of Pathology Blog.
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