The Unraveling: Cardiac and Musculoskeletal Defects and their Role in Common Alzheimer disease Morbidity and Mortality

May 21, 2020 | Histopathology

Freshly released on The American Journal of Pathology, Lab.Equipment has curated this article for your Histopath news fix:

Alzheimer disease (AD), characterized by deterioration of cognitive capabilities, is prevalent among 44 million people worldwide. Beyond memory deficits, the most common AD co-morbidities include swallowing defects (muscle), fractures (bone, muscle), and heart failure. The underlying causes of these co-morbidities and their role in AD pathophysiology are currently unknown. This review is the first to summarize the emerging picture of the cardiac and musculoskeletal deficits in human AD. We present the involvement of the heart, characterized by diastolic heart failure, the presence of amyloid deposits, and electrophysiological changes compared to age-matched controls.... Want to read more? You can view the whole article in The American Journal of Pathology Blog.

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