Tiny But Mighty: Use of Next Generation Sequencing on Discarded Cytocentrifuged Bile Duct Brushing Specimens to Increase Sensitivity of Cytological Diagnosis

Be in the know about the latest in the Pathology industry. Lab.Equipment ensures that you get your Histopath news on a day-to-day basis and only from reliable sources. Today’s article was first published on Modern Pathology

Bile duct brushing (BDB) is used to evaluate pancreatobiliary lesions as it widely samples lesions with a low complication rate. Cytological evaluation of BDB is a specific but insensitive test. There is limited literature on the use of post-cytocentrifuged (PCC) samples, which are usually discarded, for next-generation sequencing (NGS) as an adjunct to cytological diagnosis of BDB. In this study we investigate whether molecular analysis by NGS of PCC specimens improves the sensitivity of diagnosis. PCC samples from 100 consecutive BDB specimens spanning 93 unique patients were retained. DNA was extracted and mutational analysis was performed agnostic of morphologic or clinical findings. Each BDB specimen was characterized as negative, atypical or positive based on morphological analysis by trained... More of this in the Modern Pathology Blog.

In the Histopath industry and are looking for top quality Histopathology lab equipment for your facility? Go through Lab.Equipment’s selection of Pathology equipment developed by well-established brands including:

• Being Instrument
• Radwag
• Benchmark Scientific
• Troemner
• Scilogex

Acquire cost-efficient Histopath lab equipment available and ready for delivery such as:

• Laboratory Pipettes
• Laboratory Stirrers
• Lab Balances
• Lab Mixers
• Laboratory Centrifuges

Running other applications? You can rely on Lab.Equipment for needed assistance. Enhance workroom efficiency and productivity with lab equipment for other industries including microbiology, environmental, clinical, and more. Check out what you can get for your application here.