TRAF3 Modulates Cartilage Degradation Through its Suppression of Interleukin 17 Signaling

For the latest news in the Histopath industry, you can always rely on Lab.Equipment as we curate articles from trusted online sources on a day-to-day basis. Here is a new entry acquired from The American Journal of Pathology:

Interleukin 17A (IL-17A) plays critical role in the pathogenesis of autoimmune diseases through driving inflammatory cascades. However, the role of IL-17 in osteoarthritis (OA) is not well understood. TNF receptor associated factor 3 (TRAF3) is a receptor proximal negative regulator of IL-17 signaling. Whether TRAF3 exerts regulatory effects on catabolic and anabolic gene expression in chondrocytes and contributes to the pathogenesis of OA is not well understood. In this study, we found that TRAF3 notably suppressed IL-17-induced NF-κB and MAPK activation and subsequent the production of matrix-degrading enzymes.... View the full article at The American Journal of Pathology Blog.

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