TRAIL Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation and Hepatic Fibrosis in the Mdr2 -/- Mouse

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The tumor necrosis factor related apoptosis-inducing ligand (TRAIL) receptor (TR) is a pro-apoptotic receptor whose contribution to chronic cholestatic liver disease is unclear. Herein, we examined TR signaling in a mouse model of cholestatic liver injury. TRAIL receptor deficient (Tr-/-) mice were crossbred with ATP binding cassette SubfamilyB member 4 deficient (Abcb4-/- or Mdr2-/-) mice. Male and female wild type (WT), Tr-/-, Mdr2-/ - and Tr-/-Mdr2-/- mice were assessed for liver injury, fibrosis and ductular reactive (DR) cells.... More of this in the The American Journal of Pathology Blog.

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