TRIC-A Shapes Oscillatory Ca2+ Signals by Interaction with STIM1/Orai1 Complexes

April 30, 2020 | Biology

Enjoy your day-to-day Biology news fix anytime you need it thanks to Lab.Equipment's freshly curated articles from credible online sources. Check out this one first published from PLOS Biology:

by Niroj Shrestha, Bernadett Bacsa, Hwei Ling Ong, Susanne Scheruebel, Helmut Bischof, Roland Malli, Indu Suresh Ambudkar, Klaus Groschner

Trimeric intracellular cation (TRIC) channels have been proposed to modulate Ca2+ release from the endoplasmic reticulum (ER) and determine oscillatory Ca2+ signals. Here, we report that TRIC-A–mediated amplitude and frequency modulation of ryanodine receptor 2 (RyR2)-mediated Ca2+ oscillations and inositol 1,4,5-triphosphate receptor (IP3R)-induced cytosolic signals is based on attenuating store-operated Ca2+ entry (SOCE). Further, TRIC-A–dependent delay in ER Ca2+ store refilling contributes to shaping the pattern of Ca2+ oscillations. Upon ER Ca2+ depletion, TRIC-A clusters with stromal interaction molecule 1 (STIM1) and Ca2+-release–activated Ca2+ channel 1 (Orai1) within ER–plasma membrane (PM) junctions and impairs assembly of the STIM1/Orai1 complex, causing a decrease in Orai1-mediated Ca2+ current and SOCE. Together, our findings demonstrate that TRIC-A is a negative regulator of STIM1/Orai1 function. Thus, aberrant SOCE could contribute to muscle disorders associated with loss... Continue reading the article at the PLOS Biology Blog

In the Biology industry and are in need of high quality Biology lab equipment to complete your laboratory? Go through Lab.Equipment’s variety of Biology products produced by popular brands including:

Get valuable and user-friendly Biology equipment available on Lab.Equipment like:

No worries if you are handling other applications. Lab.Equipment has you covered with a range of multipurpose lab equipment to help raise your efficiency. Find accurate and precise equipment no matter for what application here.

Back To Top
We are fully compliant with the GDPR laws. We promise to safeguard your data and protect your privacy rights.