Trp53 Mutation in Krt5-expressing Basal Cells Facilitates the Development of Basal Squamous-like Invasive Bladder Cancer in the Chemical Carcinogenesis of Mouse Bladder
April 29, 2020 | Histopathology
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The biological processes of urothelial carcinogenesis are not fully understood, particularly regarding the relationship between specific genetic events, cell of origin, and molecular subtypes of subsequent tumors. N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced mouse bladder cancer is widely accepted as a useful model that recapitulates the pathway of human bladder tumorigenesis from dysplasia to invasive cancer via carcinoma in situ. However, the long and variable time of tumorigenesis often hinders efficient preclinical or translational research.... Read the entire article at The American Journal of Pathology Blog.
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