Understanding the Oxygen Sensing Pathway and Its Therapeutic Implications in Diseases

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Maintaining oxygen homeostasis is a most basic cellular process for adapting physiological oxygen variations and its abnormality typically leads to various disorders in the human body. The key molecules of the oxygen-sensing system include the transcriptional regulator hypoxia-inducible factor (HIF) which controls a wide range of oxygen responsive target genes (e.g. EPO, VEGF), the certain members of the oxygen/2-oxoglutarate dependent dioxygenases including the HIF proline hydroxylase (PHD, or EglN), and an E3 ubiquitin ligase component for HIF destruction called von Hippel-Lindau (VHL).... View the full article at the The American Journal of Pathology Blog.

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