Complement Membrane Attack Complex: New Roles, Mechanisms of Action, and Therapeutic Targets

May 11, 2020 | Histopathology

Lab.Equipment is always here to make sure you are presented with the latest Histopath industry news. Check out today's entry that first appeared on The American Journal of Pathology:

The complement membrane attack complex (MAC) is classically known as a cytolytic effector of innate and adaptive immunity that forms pores in the plasma membrane of pathogens or targeted cells leading to osmolysis. Nucleated cells resist MAC-mediated cytolysis by expression of inhibitors that block MAC assembly or by rapid removal of MAC through endocytosis or shedding. In the absence of lysis, MAC may induce intracellular signaling and cell activation, responses implicated in a variety of autoimmune, inflammatory, and transplant disease settings.... More of this in The American Journal of Pathology Blog.

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