Histopathology Industry News

Researchers from the University of London and UCLH conducted a world-first trial of a new genetic therapy that is able to safely and efficiently decrease levels of harmful tau protein known to cause Alzheimer’s disease. This gene silencing approach uses BIIB080 (/IONIS-MAPTRx), a drug classified as an antisense oligonucleaotide which...

Variations in the anatomy of the human gut were found to be significant by a group of researchers from the North Carolina State University. These pronounced differences raised numerous questions that can be further explored. Previous studies have shown the variability in the relative lengths and structure of human digestive...

During aging, stem cells that have the ability to move between growth compartments in hair follicles get stuck. This leads to losing the ability to mature and maintain hair color, suggests a new study by the NYU Langone Health and NYU Grossman School of Medicine research team. The researchers focused...

Recently, a research team from the Massachusetts General Hospital utilized targeted drugs in restoring muscle strength and correcting myotonia in mice with myotonic dystrophy. These could lead to new treatment approaches for affected patients. In myotonia, abnormal processing or splicing of the transcript leads to a truncated or poorly functioning...

HIV can cause a chronic state of inflammation and dysfunction to the immune system which contributes to organ damage. Though the reason is not yet clear, mitochondrial dysfunction seems to be a great contributor to organ damage and is present in chronic HIV. Up to date, there are still no...

It was presumed that optimal balance between levels of food consumption and exercise maximizes healthy brain aging and the reduced risk for disease. However, current manifestations of Western lifestyle and obesity has now led to greater cognitive aging and dementia in middle to older adults. To support these hypotheses, researchers...

Researchers from China found a way to diminish hangovers and other adverse outcomes of excessive alcohol consumption. The enzyme alcohol dehydrogenase (ADH) is used by the human body to metabolize alcohol. However, some variants prove to be more effective than others as numerous studies indicated. Found in East Asian and...

Researchers from the Smidt Heart Institute used deep learning and advanced imaging techniques in examining the genetics of the heart structure. Analyzing cardiac MRI images from 38,897 individuals, data underwent computational models for the identification of genetic markers of the heart that are associated with two cardiac conditions, including atrial...

Although scientists have known mitochondria’s role in the metabolism and energy production of cancer cells. However, on the level of whole tumors, only little data is available with regards to the relationship between mitochondrial networks' structural organization and their functional bioenergetic activity. Investigators from the UCLA Jonsson Comprehensive Cancer Center...

Prostate cancer is the most common cancer and he second leading cause of death among men in the United States according to the National Cancer Institute. Castration-resistant prostate cancer (CRPC), a late stage of prostate cancer, continues to have increasing incidence despite androgen blockade. TALAPRO-2, a study led by Neeraj...

A research team from the Duke University Medical Center came up with a biomarker-based clinical approach for the classification of pancreatic lesions with the highest risk of becoming cancerous. Early detection of whether cysts will develop into cancer enables preventive surgeries especially that pancreatic cancer is on the rise and...

Evidence regarding the molecular association between head injuries and increased risk for brain tumors have been lacking and undetermined. A research team, led by Prof. Simona Parrinello of the Cancer Institute from the University College London (UCL), discovered a possible mechanism that could explain the contribution of head traumas to...

In the past, having an infection with the human immunodeficiency virus (HIV) was considered incurable. The virus tends to hibernate in the genome of infected cells for extended periods of time, making it unreachable for both the immune system and antiviral drugs. Haematopoietic stem cell transplantation was the only medical...

Ginger has a reputation for activating the immune system. As a medicinal plant, questions about whether normal consumption levels of this fruity-hot root are adequate enough to achieve health effects have arisen. And if so, which specific compounds and molecular mechanisms play a role. A team led by Veronika Somoza...

A study published by a research team of the University of East Anglia (UEA) promises new treatments that are believed to be highly targeted and more effective than existing cancer immunotherapies. The treatment would work by switching on LED lights embedded close to the tumor, which would consequently activate biotherapeutic...

Techniques to isolate and examine very small quantities of extracellular vesicles (EV) as they are naturally excreted in the urine proved to be complex as it required different types of equipment. At Nagoya University in Japan, scientists attempted to solve this problem and devised a nanowire assay that could capture...

Melanonychia, the dark discoloration of the nail, poses a challenge to clinicians as it often appears to be benign but can be cancerous. Current definitive diagnosis for melanonychia commonly requires nail matrix sampling but this method causes discomfort and permanent nail dystrophy to the patient. According to Journal of Cutaneous...

In May 2021, Delta variant was designated as a variant of concern (VOC). Having a 1.4 to 1.64 increased transmissibility rate compared to Alpha VOC, it outran the other variants. Additionally, studies showed that Delta was more aggressive than the previous strains. Regardless of the causal VOC, COVID-19 pneumonia changes...

The prediction of cancer patient outcomes and overall survival rate have been realized due to computational pathology algorithms and tools. Basing from features or grades obtained from tumor histopathologic images, it can help us recognize the potential hazard factors while improving treatment planning towards precision oncology. However, there are still...

In assessing the effects of SARS-CoV-2 infection throughout pregnancy, past prenatal studies have relied on examining the histopathology of placentas and fetal structures. As is the case, SARS-CoV-2 enters the placental tissue by docking to the highly expressed angiotensin-converting enzyme 2 (ACE2) in fetal placental vessels and stromal cells in...