Genetic Activity in Prenatal Development and Early Childhood Implants Seeds of Neuropsychiatric Diseases

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From early prenatal development through childhood, the prefrontal cortex of the human brain undergoes a rush of developmental activity. In some cases, it also contains seeds of neuropsychiatric illnesses such as autism spectrum disorder and schizophrenia, according to a new genetic analysis led by researchers at Yale University and the University of California-San Francisco (UCSF).

Previous studies have identified DNA variants linked to neuropsychiatric illnesses, but it has been unclear just when those variations might trigger functional changes in the dorsal lateral prefrontal cortex, a region closely linked to neuropsychiatric, cognitive, and emotional disorders. This new study “Whole-Genome and RNA Sequencing Reveal Variation and Transcriptomic Coordination in the Developing Human Prefrontal Cortex”, published in Cell Reports, added a new dimension to prior research... You can read the full article in the GEN Blog.

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