Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli

May 15, 2020 | Histopathology

Fresh off The American Journal of Pathology, Lab.Equipment has sourced this new article for your Pathology industry news fix:

Lysosomal acid ceramidase (Ac) has been shown to be critical for ceramide hydrolysis and regulation of lysosome function and cellular homeostasis. In the present study, we generated a knockout mouse line (Asah1fl/fl/PodoCre) with a podocyte-specific deletion of the alpha subunit (main catalytic subunit) of Ac. Although no significant morphologic changes in glomeruli were observed in these mice under light microscope, severe proteinuria and albuminuria were found in these podocyte-specific KO mice compared to control genotype littermates... You can find the full article in The American Journal of Pathology Blog.

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