Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene: Role of Ceramide Accumulation in Glomeruli
May 15, 2020 | Histopathology
Fresh off The American Journal of Pathology, Lab.Equipment has sourced this new article for your Pathology industry news fix:
Lysosomal acid ceramidase (Ac) has been shown to be critical for ceramide hydrolysis and regulation of lysosome function and cellular homeostasis. In the present study, we generated a knockout mouse line (Asah1fl/fl/PodoCre) with a podocyte-specific deletion of the alpha subunit (main catalytic subunit) of Ac. Although no significant morphologic changes in glomeruli were observed in these mice under light microscope, severe proteinuria and albuminuria were found in these podocyte-specific KO mice compared to control genotype littermates... You can find the full article in The American Journal of Pathology Blog.
Working on Histopath applications and in need of premium Histopath lab equipment for your workroom? Shop Lab.Equipment’s extensive range of Histopath equipment built by globally trusted brands such as:
Find valuable and user-friendly Histopath lab equipment for various pathological tests such as:
Carrying out veterinary, forensics, microbiology applications? Count on Lab.Equipment to improve your productivity. Discover accurate lab equipment no matter for what application here.