Prognostic Perspectives of PD-L1 Combined with Tumor-infiltrating Lymphocytes, Epstein-Barr Virus, and Microsatellite Instability in Gastric Carcinomas

June 10, 2020 | Histopathology

Freshly released on Diagnostic Pathology, Lab.Equipment has sourced this interesting Histopath industry article just for you:

The prognostic potential of PD-L1 is currently unclear in gastric carcinomas, although the immune checkpoint PD-1/PD-L1 inhibitors have produced promising results in clinical trials.

We explored the prognostic implications of programmed death ligand 1 (PD-L1) in 514 consecutive surgically-resected gastric carcinomas. Overall survival and recurrence-free survival were evaluated. Immunohistochemistry for PD-L1, CD8, FOXP3, and PD-1, and molecular grouping by in situ hybridization for Epstein-Barr virus (EBV)-encoded small RNAs and multiplex PCR for microsatellite instability... More of this in the Diagnostic Pathology Blog.

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