Restoration of Regulatory T Cell Function in Dry Eye Disease by Antagonizing Substance P/neurokinin-1 Receptor

Lab.Equipment is always here to keep you informed on the current Histopathology industry news. Here is today's article first published on The American Journal of Pathology:

Substance P (SP) is a tachykinin neuropeptide, implicated in the pathogenesis of various inflammatory conditions, and a critical mediator in pain transmission. Recently, we demonstrated the role of SP in the pathogenesis of dry eye disease (DED) through its role in the maturation of antigen-presenting cells at the ocular surface following exposure to desiccating stress. However, the effect of SP on regulatory T cells (Tregs), which are functionally impaired in DED, remains unclear. The present study examined the phenotypic and functional changes in Tregs in response to SP in DED... Find the whole article at The American Journal of Pathology Blog.

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