γ-Secretase Activity is Associated with Braak Senile Plaque Stages

May 08, 2020 | Histopathology

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Amyloid β-proteins (Aβs) Aβ1-42 and Aβ1-43 are converted via two product lines of γ-secretase to Aβ1-38 and Aβ1-40. This parallel stepwise processing model of γ-secretase predicts that Aβ1-42 and Aβ1-43, and Aβ1-38 and Aβ1-40 are proportional to each other, respectively. To obtain further insight into the mechanisms of parenchymal Aβ deposition, these four Aβ species were quantified in insoluble fractions of human brains (Brodmann areas 9-11) at various Braak senile plaque (SP) stages, using specific enzyme-linked immunosorbent assays.... Want to read more? You can find the complete article in The American Journal of Pathology Blog.

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