Apoptotic Cell-directed Resolution of Lung Inflammation Requires Myeloid αv Integrin-mediated Induction of Regulatory T lymphocytes

April 16, 2020 | Histopathology

This week, Lab.Equipment has sourced a new Histopath article published from The American Journal of Pathology:

Intratracheal instillation of apoptotic cells enhances resolution of experimental lung inflammation by incompletely understood mechanisms. We report that this intervention induces functional regulatory T lymphocytes (Tregs) in mouse lung experimentally inflamed by intratracheal administration of lipopolysaccharide (LPS). Selective depletion demonstrated that Tregs were necessary for maximal apoptotic cell-directed enhancement of resolution and adoptive transfer of additional Tregs was sufficient to promote resolution without administering apoptotic cells.... More of this in the The American Journal of Pathology Blog.

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