CAR T Therapy Helps Treat Pediatric Brain Tumors

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This week, Lab.Equipment has sourced a new Biotech article published from Genetic Engineering and Biotechnology News (GEN):

Brain cancers are challenging enough to have to treat in adults, but when they recur in small children, treatment paradigms often become exponentially more difficult. However, now, a new study led by investigators at Baylor College of Medicine, Texas Children’s Hospital, and the Hospital for Sick Children (SickKids) describe a novel approach to treat medulloblastoma and ependymoma. The researchers were able to deliver appropriately targeted chimeric antigen receptor (CAR) T cell therapy directly into the cerebrospinal fluid that surrounds the tumor. Findings from the new study were published recently in Nature Medicine through an article titled “Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma.”

“Recurrences of medulloblastoma and ependymoma can be disseminated throughout the lining of the brain and spinal cord, which are bathed in cerebrospinal fluid,” explained co-senior study investigator Nabil Ahmed, MD, associate professor of pediatrics and immunology, a section of hematology-oncology at Baylor and Texas Children’s Hospital. “This location offers the opportunity to deliver therapies into the cerebrospinal fluid compartment and could provide a better chance for the therapy to reach and eliminate the tumor than administering it through the bloodstream.”

The findings support further clinical studies to evaluate this strategy to treat pediatric brain cancers, the most common cause of cancer death in childhood. Indeed, a first-in-child clinical trial currently is recruiting patients at Texas Children’s Hospital and Baylor College of Medicine to test the safety and anti-tumor efficacy of this approach (Clinicaltrials.gov identifier: NCT02442297).

“The vast majority of children with recurrent metastatic medulloblastoma or ependymoma currently have a deadly prognosis, so it is very exciting to think w... Read the entire article at the Genetic Engineering and Biotechnology News (GEN) Blog.

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