Knockdown of Long Non-coding RNAs of Maternally Expressed 3 (lncRNA-MEG3) Alleviates Hyperoxia-induced Lung Injury via Inhibiting Thioredoxin-interacting Protein (TXNIP)-mediated Pyroptosis by Binding to MicroRNA miR-18a

April 21, 2020 | Histopathology

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Long-term hyperoxia exposure may cause lung damage, with characteristic inflammation. Long non-coding RNA of maternally expressed 3 (lncRNA-MEG3) is up-regulated in lung tissues exposed to hyperoxia; however, the underlying mechanism is unclear. Hyperoxia-induced cells and mouse models were used to study these mechanisms. Molecular assays were used to detect cell viability, cytotoxicity, and expression of microRNA miR-18a, MEG3, and inflammatory cytokines. The interaction among MEG3, miR-18a, and thioredoxin-interacting protein (TXNIP) was verified and pyroptosis-related proteins analyzed... More of this in The American Journal of Pathology Blog.

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