Rab5c-mediated Endocytic Trafficking Regulates Hematopoietic Stem and Progenitor Cell Development via Notch and AKT Signaling

This week, Lab.Equipment has curated a new Bio article published from Public Library of Science Biology:

by Jian Heng, Peng Lv, Yifan Zhang, Xinjie Cheng, Lu Wang, Dongyuan Ma, Feng Liu

It is well known that various developmental signals play diverse roles in hematopoietic stem and progenitor cell (HSPC) production; however, how these signaling pathways are orchestrated remains incompletely understood. Here, we report that Rab5c is essential for HSPC specification by endocytic trafficking of Notch and AKT signaling in zebrafish embryos. Rab5c deficiency leads to defects in HSPC production. Mechanistically, Rab5c regulates hemogenic endothelium (HE) specification by endocytic trafficking of Notch ligands and receptor. We further show that the interaction between Rab5c and Appl1 in the endosome is required for the survival of HE in the ventral wall of the dorsal aorta through AKT signaling. Interestingly, Rab5c overactivation can also lead to defects in HSPC production, which is attributed to excessive endolysosomal trafficking inducing Notch signaling defect. Taken together, our fin... Read more at the PLOS Biology Blog.

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