Histopathology Industry News

Alzheimer disease (AD), characterized by deterioration of cognitive capabilities, is prevalent among 44 million people worldwide. Beyond memory deficits, the most common AD co-morbidities...

Invasive strains of Streptococcus pyogenes with significantly reduced susceptibility to beta-lactam antibiotics have been recently described. These reports have caused...

Adenosarcoma can mimic high-grade endometrial stromal sarcoma with ZC3H7B-BCOR fusion that may show entrapped glands and often exhibits diffuse BCOR expression. We encountered diffuse...

Soft tissue tumors with GLI1 gene fusions or amplifications have been recently described as a unique pathologic entity with an established risk of malignancy. We herein expand these findings...

Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is recommended in endometrial carcinomas as a screening test for Lynch syndrome, and mismatch repair deficiency (MMRd)...

NK3 homeobox 1 (NKX3-1) is widely accepted as a highly sensitive and specific marker for prostatic adenocarcinoma. Prompted by published transcriptome data showing upregulation of NKX3-1 mRNA expression...

Colon polypectomy can require an injection of a submucosal lifting agent to fully visualize and completely remove the polyp. To the best of our knowledge, this is the largest morphologic series on the...

Myogenic differentiation (MD) has been claimed to be a poor prognostic factor in dedifferentiated liposarcoma (DDLPS). To validate this, the prognostic significance of MD in a uniformly treated...

To diagnose small cell lung carcinoma (SCLC), neuroendocrine (NE) phenotype markers such as chromogranin A, synaptophysin, and CD56 are helpful. However, because they are dispensable...

Hepatoblastoma (HB) is the most common pediatric liver tumor. Though Wnt/β-catenin and Hippo cascades are implicated in HB development, studies on the crosstalk between β-catenin and Hippo downstream...

Previous studies have shown that activation of CD81, (the portal of entry of Hepatitis C virus) by agonistic antibody results in phosphorylation of Ezrin via Syk kinase. We have previously that his is associated...

Prognosis for young patients with breast cancer is generally poor, yet considerable differences in clinical outcome between individual patients exist. To understand the genetic basis of the disparate...

“Validation of new immunologic tests ain’t easy,” it’s been said; validation of new tests for human antibodies to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a particularly...

Keratocystic odontogenic tumors (KCOTs) are locally aggressive odontogenic neoplasms with recurrence rates of up to 60%. Approximately 5% of KCOTs are associated with nevoid basal cell carcinoma (Gorlin) syndrome...

Lysosomal acid ceramidase (Ac) has been shown to be critical for ceramide hydrolysis and regulation of lysosome function and cellular homeostasis. In the present study, we generated a knockout mouse line...

Accurate grading of non-muscle invasive urothelial cell carcinoma (UCC) is of major importance, however high inter-observer variability exists. A fully-automated detection and grading network...

Histamine binds to one of the four G-protein–coupled receptors expressed by large cholangiocytes. Histamine specifically increases large cholangiocyte proliferation via H2 histamine receptor...

Group A streptococcus (GAS) is a major pathogen that impacts health and economic affairs worldwide. Although the oropharynx is the primary site of infection, GAS can colonize the female genital...

Increasingly, the ß-galactoside binding lectins termed galectins are being recognized as critical regulators of cell function and organismal homeostasis. Within the context of the mucosal surface, galectins...

Cortactin is an actin-binding protein expressed in virtually all cell types. It regulates several cell functions including adhesion and migration. Cortactin overexpression is associated with increased...